Perospirone |
| Catalog No.GC39237 |
페로스피론(SM-9018 유리 염기)은 5-HT2A 수용체(Ki=0.6nM) 및 도파민 D2 수용체(Ki=1.4nM)의 경구 활성 길항제이자 5-HT1A 수용체(Ki=2.9nM)의 부분 작용제입니다. ).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 150915-41-6
Sample solution is provided at 25 µL, 10mM.
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Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic drug and has the potential for schizophrenic disease[1][2].
[1]. Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54(4):478-81. [2]. Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18(6):448-54.
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