PF-06256142 |
| Catalog No.GC65343 |
PF-06256142는 각각 33nM 및 12nM의 EC50 및 Ki를 갖는 D1 수용체의 강력하고 선택적인 CNS-침투성 및 경구 활성 작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1609583-14-3
Sample solution is provided at 25 µL, 10mM.
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PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor, with an EC50 and Ki of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease[1].
PF-06256142 exhibits IC50 values of 10 μM)[1].
PF-06256142 exhibits high oral bioavailability (rat 85%) following oral administration (rat 5 mg/kg)[1].PF-06256142 exhibits terminal elimination half-life (rat 2.3 h) following intravenous administration (rat 5.0 mg/kg)[1].
[1]. Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018 Nov 15.
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