PF-6274484 |
| Catalog No.GC44613 |
PF-6274484는 EGFR-L858R/T790M 및 WT EGFR에 대해 각각 0.14nM 및 0.18nM의 Kis를 갖는 강력한 EGFR 억제제입니다. PF-6274484는 각각 6.6 및 5.8 nM의 IC50으로 H1975 종양 세포에서 EGFR-L858R/T790M 자가인산화를 억제하고 A549 종양 세포에서 EGFR WT를 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1035638-91-5
Sample solution is provided at 25 µL, 10mM.
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PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively).
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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