Poly-D-lysine hydrobromide (M.W 30000~70000) |
| Catalog No.GC19972 |
Poly-D-lysine hydrobromide(M.W 30000~70000)는 합성 고분자 기질로서 신경 세포 배양에 가장 널리 사용되는 기질 중 하나이다. Poly-D-lysine hydrobromide(M.W 30000~70000)는 PrPC에 영향을 주지 않고 프리온에 감염된 SN56 신경모세포종 세포에서 proteinase K 내성 PrP를 제거합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 27964-99-4
Sample solution is provided at 25 µL, 10mM.
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Poly-D-lysine hydrobromide (M.W 30000~70000) is a cell non-specific attachment factor that is often used to promote the adhesion of cells to solid matrices[1]. Poly-D-lysine hydrobromide is a synthetic polypeptide composed of D-type lysine residues linked by peptide bonds to form a polymer, and each lysine residue contains approximately one HBr [2]. HBr interferes with hydrogen bonds between amino and carboxyl groups [3]. Poly-D-lysine hydrobromide increases the number of positively charged cell binding sites [4]. Poly-D-lysine hydrobromide can be used as a matrix material to help cells grow in 3D structures [5]. The molecular weight of this product is 30000~70000.
References:
[1]Liu S, Tian H, Niu Y, et al. Combined cell grafting and VPA administration facilitates neural repair through axonal regeneration and synaptogenesis in traumatic brain injury: Axonal regeneration and synaptogenesis mediate neural repair in TBI[J]. Acta biochimica et biophysica Sinica, 2022, 54(9): 1289.
[2]Manouchehri S, Zarrintaj P, Saeb M R, et al. Advanced delivery systems based on lysine or lysine polymers[J]. Molecular Pharmaceutics, 2021, 18(10): 3652-3670.
[3]Sajan D, Joseph L, Vijayan N, et al. Natural bond orbital analysis, electronic structure, non-linear properties and vibrational spectral analysis of L-histidinium bromide monohydrate: a density functional theory[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2011, 81(1): 85-98.
[4] Marukovich N I, Nesterenko A M, Ermakov Y A. Structural factors of lysine and polylysine interaction with lipid membranes[J]. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2015, 9: 40-47.
[5]Worthington K S, Do A V, Smith R, et al. Two‐photon polymerization as a tool for studying 3D printed topography‐induced stem cell fate[J]. Macromolecular bioscience, 2019, 19(2): 1800370.
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