Polygalasaponin XXXI |
| Catalog No.GC60296 |
폴리갈라사포닌 XXXI(온지사포닌 F)는 인플루엔자 바이러스 감염을 보호하기 위해 인플루엔자 인플루엔자 혈구응집소(HA) 백신의 비강내 투여에 효과적인 보조제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 79103-90-5
Sample solution is provided at 25 µL, 10mM.
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Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1].
Polygalasaponin XXXI (Onjisaponin F) also enhances anti-HA IgA and IgG Ab titers in the nasal wash, whereas Onjisaponins E and G enhances only anti-HA IgA Ab titer significantly. Polygalasaponin XXXI can induce protective immunity against intranasal infection by influenza virus[1].Polygalasaponin XXXI (Onjisaponin F) (1 or 10 µg/mL) also induces ChAT mRNA level in rat basal forebrain cells[2].
Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice[1].
[1]. T Nagai, et al. Onjisaponins, From the Root of Polygala Tenuifolia Willdenow, as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34. [2]. T Yabe, et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia, Constituents of Kampo (Japanese Herbal) Medicine, Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14.
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