Pomalidomide-PEG1-C2-N3 (Synonyms: Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50) |
| Catalog No.GC61200 |
포말리도마이드-PEG1-C2-N3은 합성된 E3 리가제 리간드-링커 접합체로, 포말리도마이드 기반 세레블론 리간드와 PROTAC 기술에 사용되는 1-유닛 PEG 링커를 통합합니다. 포말리도마이드-PEG1-C2-N3은 선택적 CDK6 PROTAC 분해자 CP-10을 설계하는 데 사용할 수 있습니다. CP-10은 2.1nM의 DC50으로 CDK6의 분해를 유도합니다.
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Cas No.: 2271036-44-1
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
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