Progesterone (Synonyms: Cyclogest, NSC 9704, NSC 64377) |
| Catalog No.GC12408 |
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Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 57-83-0
Sample solution is provided at 25 µL, 10mM.
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Progesterone is a critical hormone for the maintenance of pregnancy, menstrual cycle, endometrium and functions with its receptor [1].
Progesterone plays an important role in establishing uterine receptivity for embryo implantation. Cooperated with nuclear progesterone receptor, progesterone could damper the action(s) of E2 and BPA on Egr1 expression [2]. When tested with mouse melanoma (B16F10) cells and human melanoma (BLM) cells, progesterone treatment could significantly inhibit mouse melanoma cell growth [3]. In MCF-7 cells, progesterone activated GLI-1 in RANKL dependent manner to regulate estrogen-induced mammary carcinogenesis [4].
When tested with rats (pretreated subcutaneous progesterone or peanut oil for 5 days beginning on pregnancy day 17 and control ones), progesterone (400 and 500 μg per day) treatment enhanced maternal behavior inhibited by opioidergic [1].
Progesterone also has been shown to exhibit neuroprotective effects via modulating the phosphorylation of Akt which plays pivotal role in promoting cell growth in the brain. To assess the effects of progesterone on Akt phosphorylation, when tested with closed-skull traumatic brain injury C57BL/6 mice, after progesterone treatment phosphorylation of Akt in hippocampus increased compared to traumatic brain injury vehicle [5]. When tested with female rats, progesterone treatment asymmetricly modulated the expression of GABA (A) receptor α4 subunit in the olfactory bulb [6].
References:
[1]. Cruz, A.M., M.H. Sukikara, and F.F. L, Late pregnancy progesterone treatment as a modulatory signal for postpartum behavior. Pharmacol Biochem Behav, 2014. 27(14): p. 00348-7.
[2]. Kim, H.R., et al., Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1/2 pathway in the uterus. Reprod Toxicol, 2014. 50: p. 60-7.
[3]. Ramaraj, P. and J.L. Cox, In vitro effect of progesterone on human melanoma (BLM) cell growth. Int J Clin Exp Med, 2014. 7(11): p. 3941-53.
[4]. Boopalan, T., et al., RANKL signaling promotes progesterone mediated estrogen induced mammary carcinogenesis. Cancer Sci, 2014. 21(10): p. 12571.
[5]. Garling, R.J., et al., Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus? Neural Regen Res, 2014. 9(21): p. 1891-6.
[6]. Arbo, B.D., et al., Asymmetric effects of low doses of progesterone on GABA(A) receptor alpha4 subunit protein expression in the olfactory bulb of female rats. Can J Physiol Pharmacol, 2014. 92(12): p. 1045-9.
| Cas No. | 57-83-0 | SDF | |
| Synonyms | Cyclogest, NSC 9704, NSC 64377 | ||
| Chemical Name | (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | ||
| Canonical SMILES | CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C | ||
| Formula | C21H30O2 | M.Wt | 314.46 |
| Solubility | ≥150mg/mL in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1801 mL | 15.9003 mL | 31.8005 mL |
| 5 mM | 0.636 mL | 3.1801 mL | 6.3601 mL |
| 10 mM | 0.318 mL | 1.59 mL | 3.1801 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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