PROTAC HSP90 degrader BP3 |
| Catalog No.GC64825 |
PROTAC HSP90 분해자 BP3은 CRBN 의존 방식으로 HSP90을 강력하고 선택적으로 분해합니다. PROTAC HSP90 분해자 BP3는 MCF-7 세포(DC50=0.99μM)에서 HSP90 단백질에 특정 분해 효과가 있습니다. PROTAC HSP90 분해자 BP3는 유방암 세포의 성장을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2669072-88-0
Sample solution is provided at 25 µL, 10mM.
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PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain certain degradation effect on HSP90 protein in MCF-7 cells (DC50=0.99 µM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell[1].
PROTAC HSP90 degrader BP3 (compound 16b) (72 h) inhibits the growth of breast cancer cells (IC50=0.63 µM in MCF-7 cells, IC50=3.53 µM in MDA-MB-231 cells, IC50=0.61 µM in 4T1 cells, IC50=2.95 µM in MDA-MB-468 cells)[1].PROTAC HSP90 degrader BP3 (2 µM; 6 h) shows degradation activity in the MCF-7 cells (DC50=0.99 µM)[1].
PROTAC HSP90 degrader BP3 (40 mg/kg; i.p., daily for 12 days) inhibits tumor growth and the tumor inhibition rate is 76.41%[1].
[1]. Liu Q, et al. Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer. Eur J Med Chem. 2022, 228:114013.
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