PROTAC Mcl1 degrader-1 |
| Catalog No.GC38943 |
Cereblon 리간드를 기반으로 한 PROTAC(단백질 분해 표적 키메라)인 PROTAC Mcl1 분해자-1(화합물 C3)은 IC50이 0.78μM인 강력하고 선택적인 Mcl-1(Bcl-2 계열 구성원) 억제제입니다. PROTAC Mcl1 분해자-1은 E3 리가제 세레블론(CRBN) 결합 리간드 포말리도마이드를 Mcl-1 억제제 S1-6에 μM 범위 친화도로 도입하여 Mcl-1의 유비퀴틴화 및 프로테아좀 분해를 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2163793-38-0
Sample solution is provided at 25 µL, 10mM.
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PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity[1].
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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