PROTAC Sirt2-binding moiety 1 (Synonyms: PROTAC Sirt2-binding moiety 1) |
| Catalog No.GC34741 |
PROTAC Sirt2 결합 모이어티 1은 IC50이 2.4 μ인 선택적이고 매우 강력한 Sirtuin 2(Sirt2) 억제제입니다. PROTAC Sirt2 결합 모이어티 1, SirReal1 기반 모이어티는 링커를 통해 세레블론 리간드에 결합하여 PROTAC을 형성하여 Sirt2를 분해합니다.
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Cas No.: 1862237-99-7
Sample solution is provided at 25 µL, 10mM.
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PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1]. IC50: 2.4 μM (Sirt2)[1].
[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
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