PSNCBAM-1 |
| Catalog No.GC50143 |
PSNCBAM-1은 EC50이 0.1μM인 선택적 CB1 수용체 알로스테릭 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 877202-74-9
Sample solution is provided at 25 µL, 10mM.
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CB1 receptor negative allosteric modulator (IC50 values are 45 and 209 nM for the inhibition of CP 55,940 and WIN 55,212-2 respectively). Has no effect at the CB2 receptor. Decreases food intake and body weight in rats.
Horswill et al (2007) PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br.J.Pharmacol. 152 805 PMID:17592509 |German et al (2014) Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J.Med.Chem. 57 7758 PMID:25162172
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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