PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) (Synonyms: DPPI3,4,5P3, Phosphatidylinositol3,4,5triphosphate C16) |
| Catalog No.GC44750 |
The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1628353-02-5
Sample solution is provided at 25 µL, 10mM.
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The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references and .
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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