Quinine (Synonyms: NSC 192949) |
| Catalog No.GC41455 |
퀴닌은 알칼로이드 항말라리아제로, 태국에서 분리된 P균주 60개에 대해 MIC 값이 10~500 nM 범위 내에 있습니다.
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Cas No.: 130-95-0
Sample solution is provided at 25 µL, 10mM.
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Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum. It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine . In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg. Formulations containing quinine have been used in the treatment of uncomplicated malaria.
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