rac-CCT 250863 |
| Catalog No.GC50063 |
rac-CCT 250863(화합물 rac-21)은 IC50이 0.073μM인 선택적이고 가역적인 NEK 2 억제제입니다. rac-CCT 250863은 세포 주기 정지를 유도하는 좋은 효과를 보여주고 세포에서 항증식할 수도 있습니다(포말리도마이드 민감성/저항성). rac-CCT 250863은 포말리도마이드와 결합할 때 세포자멸사를 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1364269-06-6
Sample solution is provided at 25 µL, 10mM.
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Potent Nek2 inhibitor (IC50 = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
Innocenti et al (2012) Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J.Med.Chem. 55 3228 PMID:22404346
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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