RAGE 229 |
| Catalog No.GC70997 |
RAGE 229 는 경구 활성 ctRAGE-DIAPH1 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2143072-85-7
Sample solution is provided at 25 µL, 10mM.
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RAGE229 has affinity for the ctRAGE with KDvalue of 2 nM and inhibits SMC migration with an IC50 value of 26 nM[1].
RAGE229 (oral gavage, 5 mg/kg, twice daily, for 4 days) assuages short- and long-term complications of diabetes in mice[1].
RAGE229 (oral or iv.; 150, 50 and 15 ppm chow; 30, 10, and 3 mg/kg per day per mouse) (5 mg/kg, ip. , every 12 hours for four total doses) reduces plasma concentrations of TNF-α, IL-6, and CCL2/JE-MCP1 in diabetic mice, and reduces pathological and functional indices of diabetes-like kidney disease[1].
References:
[1]. Michaele B Manigrasso, et al. Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Sci Transl Med. 2021 Nov 24;13(621):eabf7084.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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