RAS inhibitor Abd-7 |
| Catalog No.GC62421 |
강력한 RAS-결합 화합물(Kd=51nM)인 RAS 억제제 Abd-7은 RAS-이펙터 단백질-단백질 상호작용(PPI) 억제제입니다. RAS 억제제 Abd-7은 세포 내부의 RAS와 상호작용하고, RAS-이펙터 상호작용을 방지하고, 내인성 RAS 의존적 신호전달을 억제합니다. RAS 억제제 Abd-7은 PI3K, CRAF 및 RALGDS뿐만 아니라 NRAS Q61H 및 HRAS G12V를 사용하여 다양한 돌연변이 KRAS 단백질의 PPI를 손상시킵니다.
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Cas No.: 2351843-48-4
Sample solution is provided at 25 µL, 10mM.
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RAS inhibitor Abd-7, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V[1].
RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range[1].
[1]. Quevedo CE, et al. Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun. 2018;9(1):3169. Published 2018 Aug 9.
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