RBPJ Inhibitor-1 (Synonyms: RIN1) |
| Catalog No.GC61233 |
최초의 RBPJ 억제제인 RBPJ 억제제-1(RIN1)은 RBPJ와 SHARP의 기능적 상호작용을 차단합니다. RBPJ 억제제-1(RIN1)은 NOTCH 의존성 종양 세포 증식을 억제합니다.
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Cas No.: 2682114-39-0
Sample solution is provided at 25 µL, 10mM.
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RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation[1].
RIN1 inhibits the proliferation of hematologic cancer cell lines and promoted skeletal muscle diferentiation from C2C12 myoblasts[1].RIN1 (0.6 µM, corresponding to 3 × IC50) decreases the number of MHC+ cells and increased the number of nuclei per cell, indicating that it induces the formation of multinucleated myofbers[1]. Cell Viability Assay[1] Cell Line: AD-293 cells were transfected with RBPJ-VP16myc.
[1]. Cecilia Hurtado, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9(1):10811.
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