>>Signaling Pathways>> Proteases>> Drug Metabolite>>Regorafénib N-oxyde M2

Regorafénib N-oxyde M2

Catalog No.GC33333

레고라페닙 N-옥시드 M2는 레고라페닙의 활성 대사산물입니다. 레고라페닙은 IC50이 각각 13/4.2/46, 22, 7, 1.5 및 2.5nM인 VEGFR1/2/3, PDGFRβ, Kit, RET 및 Raf-1에 대한 다중 표적 억제제입니다.

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Regorafénib N-oxyde M2 Chemical Structure

Cas No.: 835621-11-9

Size 가격 재고 수량
5mg
US$102.00
재고 있음
10mg
US$167.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

[1]. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.

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