2OH-BNPP1 |
Catalog No.GC34080 |
2OH-BNPP1은 암 치료에 사용되는 Ser/Thr 키나제인 BUB1 키나제의 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 833481-73-5
Sample solution is provided at 25 µL, 10mM.
2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.
2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines[1].
2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice[1].
[1]. Nyati S, et al. The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Sci Signal. 2015 Jan 6;8(358):ra1.
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