>>Signaling Pathways>> Proteases>> Drug Metabolite>>5,6-dihydro-5-Fluorouracil

5,6-dihydro-5-Fluorouracil (Synonyms: 5-DHFU, 5-Fluorodihydropyrimidine-2,4-dione, 5-Fluorodihydrouracil, 5-Fluoro-5,6-dihydrouracil, 5-FUH2)

Catalog No.GC18542

5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD).

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5,6-dihydro-5-Fluorouracil Chemical Structure

Cas No.: 696-06-0

Size 가격 재고 수량
5mg
US$121.00
재고 있음
10mg
US$226.00
재고 있음
25mg
US$535.00
재고 있음
50mg
US$1,007.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD). Formulations containing 5-FU are used for the treatment of cancer. However, in patients lacking full DPD activity, severe adverse events, including death, can occur. 5-FUH2 is less toxic than 5-FU but is not as effective (IC50s = 3.3 and 560 uM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells).

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