7ACC2 |
| Catalog No.GC14642 |
7ACC2는 [14C]-락테이트 유입을 억제하기 위해 IC50이 11nM인 강력한 MCT(모노카르복실레이트 수송체) 억제제입니다. 7ACC2는 또한 미토콘드리아 피루브산 수송의 강력한 억제제입니다. 7ACC2는 젖산유속 억제를 통한 항암제이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1472624-85-3
Sample solution is provided at 25 µL, 10mM.
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7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.
References:
[1]. Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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