Acetyl phosphate(lithium potassium)

Acetyl phosphate(lithium potassium) is an organometallic compound used as a phosphoryl donor and is commonly used in protein phosphorylation reactions^[1]. Acetyl phosphate (lithium potassium) is an endogenous compound involved in taurine and hypotaurine metabolism and pyruvate metabolism^[2]. Acetyl phosphate (lithium potassium) is produced from sulfoacetaldehyde and converted to acetyl-CoA and acetate by phosphate acetyltransferase and acetate kinase, respectively^[3]. Acetyl phosphate (lithium potassium) is also an intermediate in pyruvate metabolism^[4]. Acetyl phosphate (lithium potassium) is suitable as an acetyl phosphate source, which is useful for reducing the formation of inorganic monophosphate byproducts by replacing inorganic oligophosphates in phosphatase-catalyzed transphosphorylation^[5].

References:
[1]Li D Y, Han J T, Zhang M Y, et al. The two-component system RstA/RstB regulates expression of multiple efflux pumps and influences anaerobic nitrate respiration in Pseudomonas fluorescens[J]. Msystems, 2021, 6(6): e00911-21.
[2]Nciri R, Desmoulin F, Allagui M S, et al. Neuroprotective effects of chronic exposure of SH-SY5Y to low lithium concentration involve glycolysis stimulation, extracellular pyruvate accumulation and resistance to oxidative stress[J]. International Journal of Neuropsychopharmacology, 2013, 16(2): 365-376.
[3]Ruff J, Denger K, Cook A M. Sulphoacetaldehyde acetyltransferase yields acetyl phosphate: purification from Alcaligenes defragrans and gene clusters in taurine degradation[J]. Biochemical Journal, 2003, 369(2): 275-285.
[4]Fan T W M, Yuan P, Lane A N, et al. Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions[J]. Metabolomics, 2010, 6: 165-179.
[5]Johnson D C, Widlanski T S. Overview of the synthesis of nucleoside phosphates and polyphosphates[J]. Current protocols in nucleic acid chemistry, 2003, 15(1): 13.1. 1-13.1. 31.