>>Signaling Pathways>> Microbiology & Virology>> HCV>>ACH-806 (GS9132)

ACH-806 (GS9132) (Synonyms: GS9132)

Catalog No.GC32305

ACH-806(GS9132)은 14nM의 EC50으로 C형 간염 바이러스(HCV) 복제를 억제할 수 있는 NS4A 길항제입니다.

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ACH-806 (GS9132) Chemical Structure

Cas No.: 870142-71-5

Size 가격 재고 수량
1mg
US$690.00
재고 있음
5mg
US$1,105.00
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10mg
US$1,767.00
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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

ACH-806 is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.

ACH-806 is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM. ACH-806 treatment results in significant reductions of both NS3 and NS4A in the transfected cells. This finding is reminiscent of ACH-806-treated replicon cells in which the amounts of NS3 and NS4A are also both decreased. The total amount of NS3 in the ACH-806-treated sample is reduced by ~6-fold (100/16) and causes a reduction of NS4A-bound NS3 ~29-fold (261/9). The levels of labeled NS3 and NS4A immunoprecipitated by anti-NS3 antibody are apparently reduced after the treatment of ACH-806. ACH-806 also induces significant decreases of NS3 and NS4A and promotes p14 formation in the parental replicon cells but not in the ACH-806-resistant replicon cells[1].

[1]. Yang W, et al. ACH-806, an NS4A antagonist, inhibits hepatitis C virus replication by altering the composition of viral replication complexes. Antimicrob Agents Chemother. 2013 Jul;57(7):3168-77.

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