AGN194204 (Synonyms: IRX4204; NRX194204; VTP 194204) |
Catalog No.GC39584 |
AGN194204 (IRX4204)는 RXRα, RXRβ 및 RXRγ에 대한 Kd 값이 각각 0.4 nM, 3.6 nM 및 3.8 nM이며, 이들에 대한 EC50은 각각 0.2 nM, 0.8 nM 및 0.08 nM인 경구 흡수 가능하고 선택적인 RXR 작용제입니다.
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Cas No.: 220619-73-8
Sample solution is provided at 25 µL, 10mM.
AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions[1][2].
[1]. Liby K, et al. A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland. Clin Cancer Res. 2007 Oct 15;13(20):6237-43. [2]. Vuligonda V, et al. Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. J Med Chem. 2001 Jul 5;44(14):2298-303.
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