ARN-3236 |
| Catalog No.GC33070 |
ARN-3236은 SIK2, SIK1 및 SIK3에 대해 각각 IC50이 1nM 미만, 21.63nM 및 6.63nM인 염유도성 키나제 2(SIK2)의 경구 활성 및 선택적 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1613710-01-2
Sample solution is provided at 25 µL, 10mM.
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ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2) (IC50 <1 nM), with activity in inhibiting growth and enhancing paclitaxel sensitivity in cultures and xenografts of ovarian cancer cell lines[1][2].
[1]. Lombardi MS, et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99(5):711-21. [2]. Zhou J, et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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