AZD5904 |
| Catalog No.GC30783 |
AZD5904는 IC50이 140nM인 인간 골수과산화효소(MPO)의 선택적이고 비가역적인 억제제이며 마우스와 래트에서 유사한 효능을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 618913-30-7
Sample solution is provided at 25 µL, 10mM.
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AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.
AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase; >70-fold to a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 µM AZD5904 inhibits PMA stimulated HOCl by >90%[1].
[1]. Myeloperoxidase (MPO) inhibitor.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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