BAY-293 |
| Catalog No.GC33186 |
가치 있는 화학 프로브인 BAY-293은 KRAS-SOS1과 21nM의 IC50 상호작용을 방해하여 RAS 활성화를 차단합니다. BAY-293은 Son of Sevenless 1(SOS1)의 강력한 억제제입니다. SOS1은 구아닌 뉴클레오티드 교환 인자(GEF)이자 RAS의 활성제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244904-70-7
Sample solution is provided at 25 µL, 10mM.
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BAY-293 is a potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction with an IC50 of 21 nM[1].
[1]. Hillig RC, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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