CAY10621 (Synonyms: SKI 5C, SPHK1 Inhibitor 5C) |
| Catalog No.GC43183 |
CAY10621(SKI 5C; 화합물 5c)은 IC50이 3.3μM인 특정 스핑고신 키나제 1(SPHK1) 억제제입니다. CAY10621은 세포에 대한 독성이 낮습니다. CAY10621은 내성 암 종양 연구에 대한 잠재력이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 120005-55-2
Sample solution is provided at 25 µL, 10mM.
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CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1; IC50 = 3.3 μM).[1] It is selective for SPHK1 over SPHK2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 μM.
Reference:
1. Wong, L., Tan, S.L., Lam, Y., et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. Journal of Medicinal Chemistry 52, 3618-3626 (2009).
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