CH5424802 (Synonyms: Alectinib, RO5424802) |
Catalog No.GC16025 |
CH5424802(CH5424802)는 1.9 nM의 IC50 및 2.4 nM의 Kd 값(ATP-경쟁적 방식으로)을 갖는 강력하고 선택적이고 경구적으로 이용 가능한 ALK 억제제이며, 또한 및 각각 3.5nM. CH5424802는 효과적인 중추신경계(CNS) 침투를 보여줍니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1256580-46-7
Sample solution is provided at 25 µL, 10mM.
CH5424802 is a potent and selective ALK inhibitor.
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase that is constitutively activated in certain cancers. .
In vitro: In cell free assays the IC50 of CH5424802 for enzyme activity of ALK was 1.9 nM; the dissociation constant (KD) value for ALK in an ATP-competitive manner was 2.4 nM. The inhibitory activity for two hot spot-activating mutations (F1174L and R1275Q) in neuroblastoma was comparable to that for wildtype ALK [1].
In vivo: In the NCI-H2228 model, oral administration of CH5424802 resulted in dose-dependent tumor growth inhibition (ED50 = 0.46 mg/kg) and tumor regression. Moreover, treatment of 20 mg/kg CH5424802 showed rapid tumor regression and tumor regrowth did not occur throughout the 4-week drug-free period [2].
Clinical trial: No clinical data are available currently.
Reference:
[1] Sakamoto H, Tsukaguchi T, Hiroshima S, Kodama T, Kobayashi T, Fukami TA, Oikawa N, Tsukuda T, Ishii N, Aoki Y. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011 May 17;19(5):679-90.
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