Eprotirome (KB2115) (Synonyms: Eprotirome) |
Catalog No.GC33764 |
에프로티롬(KB2115)(KB2115)은 간 선택적 갑상선 호르몬 수용체(TR) 작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 355129-15-6
Sample solution is provided at 25 µL, 10mM.
Eprotirome is a liver-selective thyroid hormone receptor agonist.
Eprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice[1].
[1]. Martagón AJ, et al. The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PLoS One. 2015 Apr 7;10(4):e0122987.
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