Ganoderic Acid D |
| Catalog No.GC40900 |
Ganoderma lucidum의 주요 활성 성분인 Ganoderic acid D는 고도로 산소화된 tetracyclic triterpenoid입니다. Ganoderic acid D는 SIRT3의 단백질 발현을 상향 조절하고 SIRT3에 의해 탈아세틸화된 사이클로필린 D(CypD)를 유도합니다. 가노데르산 D는 결장암 세포에서 포도당 흡수, 젖산 생산, 피루브산 및 아세틸 조효소 생산을 포함한 결장암 세포의 에너지 재프로그래밍을 억제합니다. Ganoderic acid D는 HeLa 인간 자궁 경부암 세포 사멸을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108340-60-9
Sample solution is provided at 25 µL, 10mM.
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Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1].
Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].
References:
[1]. Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77.
[2]. Yue QX,et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61.
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