Dehydroeffusol |
| Catalog No.GC35834 |
Dehydroeffusol은 약초 Juncus effuses의 페난트렌입니다. Dehydroeffusol은 종양 억제 소포체 스트레스와 중간 정도의 세포 사멸을 선택적으로 유도하여 위암 세포의 성장과 종양 형성을 억제합니다. 매우 낮은 독성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 137319-34-7
Sample solution is provided at 25 µL, 10mM.
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Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity[1][2].
Dehydroeffusol suppresses the expression of vasculogenic mimicry key gene VE-cadherin[2].Dehydroeffusol decreases the MMP2 expression and activity in gastric cancer cells[2].
[1]. Zhang B, et al. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. Biochem Pharmacol. 2016 Mar 15;104:8-18. [2]. Liu W, et al. Dehydroeffusol effectively inhibits human gastric cancer cell-mediated vasculogenic mimicry with low toxicity. Toxicol Appl Pharmacol. 2015 Sep 1;287(2):98-110.
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