MC-Val-Cit-PAB-dimethylDNA31 |
| Catalog No.GC36570 |
MC-Val-Cit-PAB-디메틸DNA31은 ADC 링커 MC-Val-Cit-PAB를 통해 연결된 디메틸DNA31을 사용하여 강력한 항종양 활성을 갖는 ADC용 약물-링커 접합체입니다. DimethylDNA31은 지속균 및 정지기 S. aureus에 대해 효과적인 살균 활성을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1639352-06-9
Sample solution is provided at 25 µL, 10mM.
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MC-Val-Cit-PAB-dimethylDNA31 has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-dimethylDNA31 is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].
[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.
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