MS023 dihydrochloride |
| Catalog No.GC36655 |
MS023 디히드로클로라이드는 PRMT1, PRMT3, PRMT4, PRMT6 및 PRMT8에 대해 IC50이 30, 119, 83, 4 및 5 nM인 인간 I형 단백질 아르기닌 메틸트랜스퍼라제(PRMT) 억제제의 강력하고 선택적인 세포 활성 억제제입니다. 각기.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1992047-64-9
Sample solution is provided at 25 µL, 10mM.
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MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1]. IC50: 30 nM (PRMT1), 119 nM (PRMT3), 83 nM (PRMT4), 4 nM (PRMT6), 5 nM (PRMT8)[1]
MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells[1]. MS023(1-1000 nM; 20 hours) inhibits PRMT6 methyltransferase activity in HEK293 cells[1]. Western Blot Analysis[1] Cell Line: MCF7 and HEK293 cells
[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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