APX-115 free base (Synonyms: Ewha-18278 free base) |
Catalog No.GC38115 |
APX-115 유리 염기(Ewha-18278 유리 염기)는 Nox1, Nox2 및 Nox4에 대해 각각 Ki 값이 1.08μM, 0.57μM 및 0.63μM인 강력한 경구 활성 범 NADPH 산화효소(Nox) 억제제입니다.
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Cas No.: 1270084-92-8
Sample solution is provided at 25 µL, 10mM.
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].
[1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.
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