DPA-714 |
| Catalog No.GC38384 |
DPA-714는 고친화성 전위 단백질(TSPO) 리간드(Ki=7 nM)로 구조에 불소 원자를 포함하도록 설계되어 불소 -18로 표지화하고 양전자 방출 단층 촬영을 사용한 생체 내 이미징이 가능합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 958233-07-3
Sample solution is provided at 25 µL, 10mM.
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DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. [18F]DPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model[1][2].
[1]. James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49(5):814-22. [2]. Harhausen D, et al. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. PLoS One. 2013 Aug 2;8(8):e69529.
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