S29434 (Synonyms: NMDPEF) |
| Catalog No.GC38451 |
S29434(NMDPEF)는 퀴논 환원효소 2(QR2)의 강력하고 경쟁적이며 선택적인 세포 투과성 억제제이며 IC50은 다양한 조직 수준에서 인간 QR2에 대해 5~16nM 범위이며 QR1보다 QR2에 대해 우수한 선택성을 가지고 있습니다.
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Cas No.: 874484-20-5
Sample solution is provided at 25 µL, 10mM.
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S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 (NMDPEF) induces autophagy and inhibits QR2-mediated ROS production[1].
[1]. Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285.
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