α-Linolenic Acid-d5 MaxSpec• Standard (Synonyms: ALA-d5, C18:3 (9Z,12Z,15Z)-d5, C18:3 n-3-d5)

α-Linolenic acid-d5 (ALA-d5) is intended for use as an internal standard for the quantification of ALA by GC- or LC-MS. α-Linolenic acid is an essential ω-3 polyunsaturated fatty acid found in plants.1 In vivo, it is converted to the longer-chain fatty acids eicosapentaenoic , docosapentaenoic , and docosahexaenoic acid .2 It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of ALA-containing foods is positively associated with a moderately lower risk of cardiovascular disease.1 ALA-d5 MaxSpec• standard is a quantitative grade standard of ALA-d5 that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This ALA-d5 MaxSpec• standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

References
1. Pan, A., Chen, M., Chowdhury, R., et al. α-Linolenic acid and risk of cardiovascular disease: A systematic review and meta-analysis. Am. J. Clin. Nutr. 96(6), 1262-1273 (2012).
2. Burdge, G.C. Metabolism of α-linolenic acid in humans. Prostaglandins Leukot. Essent. Fatty Acids 75(3), 161-168 (2006).