Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) (Synonyms: 4-Isothioureidobutyronitrile, NSC 525990) |
| Catalog No.GC32919 |
케베트린 염산염(4-이소티오우레이도부티로니트릴 염산염)은 p53의 강력한 활성제이며 TP53 야생형 및 돌연변이 급성 골수성 백혈병 세포에서 세포자멸사를 유도합니다. 케베트린은 아세포에 대한 우선적인 세포독성 활성입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66592-89-0
Sample solution is provided at 25 µL, 10mM.
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Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target:p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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