KW-8232 free base |
| Catalog No.GC31633 |
KW-8232 유리 염기는 경구 활성 항골다공증제이며 PGE2의 생합성을 감소시킬 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 170365-25-0
Sample solution is provided at 25 µL, 10mM.
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KW-8232 free base is an anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
KW-8232 free base is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].
KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1].
[1]. Uchii M, et al. Effect of KW-8232, a novel anti-osteoporotic agent, on bone loss in sciatic neurectomized rats. Jpn J Pharmacol. 1998 Oct;78(2):241-3.
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