L-701,324 |
| Catalog No.GC14810 |
L-701,324는 글리신 B 결합 부위를 차단하여 NMDA 수용체의 활성을 길항하는 강력한 경구 활성 NMDA 수용체 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 142326-59-8
Sample solution is provided at 25 µL, 10mM.
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L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Target: NMDA ReceptorL-701324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.).
References:
[1]. Piotr Wlaz, et al. Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice. Pharmacological Reports 2011,63,1231-1234
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