Licarin A |
| Catalog No.GC60225 |
네오리그난인 리카린 A((+)-리카린 A)는 디니트로페닐-인간 혈청 알부민(DNP-HSA)으로 자극된 RBL-2H3 세포에서 TNF-α 생산(IC50=12.6μM)을 용량 의존적으로 현저하게 감소시킵니다. .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 51020-86-1
Sample solution is provided at 25 µL, 10mM.
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Licarin A ((+)-Licarin A), a neolignan isolated from various plants, significantly and dose-dependently reduces TNF-α production (IC50=12.6±0.3 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression[1].
Licarin A is found in plants such as Aristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects[1]. Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels[1].
[1]. Takuya Matsui, et al. Licarin A Is a Candidate Compound for the Treatment of Immediate Hypersensitivity via Inhibition of Rat Mast Cell Line RBL-2H3 Cells. J Pharm Pharmacol. 2015 Dec;67(12):1723-32.
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