Mps1-IN-1 dihydrochloride |
| Catalog No.GC50110 |
Mps1-IN-1 이염산염은 IC50이 367 nM인 강력하고 ATP 경쟁적인 Mps1 키나제 억제제입니다. Mps1-IN-1 이염산염은 Mps1 유사분열 키나제 활성을 억제하고 SAC(스핀들 어셈블리 체크포인트) 기능을 폐지합니다. Mps1-IN-1 이염산염은 암 세포와 '정상' 세포 모두의 생존력을 감소시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883548-93-3
Sample solution is provided at 25 µL, 10mM.
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Selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.
Kwiatkowski et al (2010) Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 6 359 PMID:20383151 |Miduturu et al (2011) High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 18 868 PMID:21802008 |Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 190 21 PMID:20624898
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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