>>Signaling Pathways>> Ubiquitination/ Proteasome>> p97>>MSC1094308

MSC1094308

Catalog No.GC60257

MSC1094308은 비경쟁적이고 가역적인 VPS4B/p97(VCP)(I/II 유형 AAA ATPase) 알로스테릭 억제제이며 VPS4B 및 p97에 대해 IC50 값이 각각 0.71μM 및 7.2μM입니다. MSC1094308은 p97의 약물 가능한 핫스팟에 결합하여 D2 ATPase 활성을 억제합니다. MSC1094308은 암 연구에 사용할 수 있습니다.

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MSC1094308 Chemical Structure

Cas No.: 2219320-08-6

Size 가격 재고 수량
5mg
US$86.00
재고 있음
10mg
US$135.00
재고 있음
50mg
US$459.00
재고 있음
100mg
US$783.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1].

[1]. PÖhler R, et al. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.

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Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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