MSC1094308 |
Catalog No.GC60257 |
MSC1094308은 비경쟁적이고 가역적인 VPS4B/p97(VCP)(I/II 유형 AAA ATPase) 알로스테릭 억제제이며 VPS4B 및 p97에 대해 IC50 값이 각각 0.71μM 및 7.2μM입니다. MSC1094308은 p97의 약물 가능한 핫스팟에 결합하여 D2 ATPase 활성을 억제합니다. MSC1094308은 암 연구에 사용할 수 있습니다.
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Cas No.: 2219320-08-6
Sample solution is provided at 25 µL, 10mM.
MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1].
[1]. PÖhler R, et al. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.
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