Nemadipine A |
| Catalog No.GC44361 |
Nemadipine A는 EGL-19 L형 Ca2+ 채널의 특정 억제제입니다. 세포 투과성 L형 칼슘 채널 억제제인 \u200b\u200b네마디핀 A는 TRAIL 내성 암세포를 이 리간드에 민감하게 만듭니다.
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Cas No.: 54280-71-6
Sample solution is provided at 25 µL, 10mM.
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Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
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