O-Desmethyl Midostaurin (Synonyms: CGP62221; O-Desmethyl PKC412) |
| Catalog No.GC60274 |
O-데스메틸 미도스타우린(CGP62221; O-데스메틸 PKC412)은 시토크롬 P450 간 효소 대사를 통한 미도스타우린의 활성 대사 산물입니다. O-데스메틸 미도스타우린은 생체내 미도스타우린 대사에 대한 지표로 사용될 수 있습니다. 미도스타우린은 IC50이 22-500nM 범위인 다중 표적 단백질 키나제 억제제입니다.
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Cas No.: 740816-86-8
Sample solution is provided at 25 µL, 10mM.
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O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83.
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