PACAP (1-27) (human, mouse, ovine, porcine, rat) (trifluoroacetate salt) (Synonyms: Pituitary Adenylate Cyclase-activating Peptide (1-27)) |
| Catalog No.GC44531 |
Pituitary adenylate cyclase-activating peptide (PACAP) (1-27) is a PACAP receptor agonist with IC50 values of 3, 2, and 5 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Pituitary adenylate cyclase-activating peptide (PACAP) (1-27) is a PACAP receptor agonist with IC50 values of 3, 2, and 5 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors in rat brain membrane (IC50 = 9.55 nM) and to SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 1.1, 1.9, and 0.9 nM, respectively). PACAP (1-27) stimulates cAMP accumulation in H-SY5Y, SK-N-MC, and T47D cells (EC50s = 0.19, 0.22, and 0.17 nM, respectively). In vivo, in newborn pigs, PACAP (1-27) (1 μM) induces vasodilation of pial arterioles by 36%.
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