PROTAC Sirt2 Degrader-1 |
| Catalog No.GC33418 |
PROTAC Sirt2 Degrader-1은 SirReal 기반 PROTAC으로 매우 강력하고 isotype-selective Sirt2 억제제, 링커 및 E3 유비퀴틴 리가아제에 대한 진정한 Cereblon 리간드로 구성된 Sirt2 분해자 역할을 합니다. PROTAC Sirt2 Degrader-1은 Sirt2에 대해 0.25μM의 IC50을 보여주며 Sirt1/Sirt3에는 영향을 미치지 않습니다(IC50s>100μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2098487-75-1
Sample solution is provided at 25 µL, 10mM.
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PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker and thalidomide, a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1].|| Western Blot Analysis[1]||Cell Line:|HeLa cells|Concentration:|10 µM|Incubation Time:|1-6 hours|Result:|Caused Sirt2 degradation, but showed no effect on Sirt1 levels.
[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
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