Pyr3 |
| Catalog No.GC14649 |
Pyr3은 TRPC3 매개 Ca2+ 유입에 대한 IC50이 700nM인 TRPC3(과도 수용체 전위 표준 채널 3)의 선택적 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1160514-60-2
Sample solution is provided at 25 µL, 10mM.
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Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC50 of 700 nM for TRPC3-mediated Ca2+ influx.
Pyr3 selectively and directly inhibits TRPC3 channels among TRPC family members. Application of Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with the IC50 value of 700 nM. Pyr3 becomes apparent at 0.3 μM, and is almost complete at 3 μM. Interestingly, Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells coexpressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3, but weakly by Pyr2 in a concentration-dependent manner (IC50 value was 0.05 μM for Pyr3 and 2 μM for Pyr2)[1].
References:
[1]. Kiyonaka S, et al. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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