Ranitidine hydrochloride |
| Catalog No.GC12365 |
라니티딘 염산염은 위 분비를 억제하는 IC50이 3.3μM인 강력하고 선택적이며 경구 활성인 히스타민 H2 수용체 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66357-59-3
Sample solution is provided at 25 µL, 10mM.
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Ranitidine hydrochloride is a histamine H2-receptor antagonist that inhibits stomach acid production. Target: Histamine H2-ReceptorRanitidine hydrochloride is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 uM. It inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions [1, 2].
References:
[1]. Herling, A.W., et al., Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9.
[2]. Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81.
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